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Trastuzumab Deruxtecan in Previously Treated HER2-Low …
WEBJun 5, 2022 · trastuzumab deruxtecan (formerly DS-8201), an antibody–drug conjugate consisting of a humanized anti-HER2 monoclonal antibody linked to a topoisomerase I inhibitor payload through a
Nejm.orgEnhertu Approved for Any HER2-Positive Solid Cancer - NCI
WEBMay 3, 2024 · The drug trastuzumab deruxtecan (Enhertu) can now be used to treat a wide variety of cancers, thanks to a new approval from the Food and Drug Administration (FDA).
Cancer.govTrastuzumab Deruxtecan versus Trastuzumab Emtansine for …
WEBMar 23, 2022 · Treatment with trastuzumab deruxtecan showed a benefit over trastuzumab emtansine with respect to progression-free survival, as assessed by blinded independent central review.
Nejm.orgTrastuzumab deruxtecan - Wikipedia
WEBtrastuzumab deruxtecan, sold under the brand name Enhertu, is an antibody-drug conjugate consisting of the humanized monoclonal antibody trastuzumab (Herceptin) covalently linked to the topoisomerase I inhibitor deruxtecan (a derivative of exatecan). It is licensed for the treatment of breast cancer or gastric or gastroesophageal adenocarcinoma.
En.wikipedia.orgEfficacy and Safety of Trastuzumab Deruxtecan in Patients With …
WEBOct 23, 2023 · trastuzumab deruxtecan (T-DXd) is a human epidermal growth factor 2 (HER2)–directed antibody-drug conjugate approved in HER2-expressing breast and gastric cancers and HER2-mutant non–small-cell lung cancer.
Ascopubs.orgTrastuzumab Deruxtecan in Previously Treated HER2-Positive …
WEBDec 11, 2019 · trastuzumab deruxtecan showed durable antitumor activity in a pretreated patient population with HER2-positive metastatic breast cancer. In addition to nausea and myelosuppression, interstitial
Nejm.orgTrastuzumab Deruxtecan for Metastatic HER2-Low Breast Cancer
WEBJul 5, 2022 · trastuzumab deruxtecan, also known as T-DXd, “is the first HER2- targeted therapy shown to provide clinically meaningful improvement in progression-free and overall survival compared with standard chemotherapy in people with HER2-low metastatic breast cancer,” Dr. Modi said at the meeting.
Cancer.govFDA approval summary: fam-trastuzumab deruxtecan-nxki for
WEBJul 6, 2024 · On August 11, 2022, FDA granted accelerated approval to fam-trastuzumab deruxtecan-nxki (DS-8201a, T-DXd, ENHERTU, Daiichi Sankyo) for adult patients with unresectable or metastatic non-small cell lung cancer (NSCLC) whose tumors have activating human epidermal growth factor receptor 2 (HER2) mutati …
Pubmed.ncbi.nlm.nih.govTrastuzumab Deruxtecan (DS-8201a): The Latest Research and - PubMed
WEBtrastuzumab deruxtecan (DS-8201a) is a next-generation antibody-drug conjugate composed of a monoclonal anti-HER2 antibody and a topoisomerase I inhibitor, an exatecan derivative (DX-8951f).
Pubmed.ncbi.nlm.nih.govTrastuzumab deruxtecan in metastatic breast cancer with - Nature
WEBJul 24, 2023 · trastuzumab deruxtecan, an anti-HER2–drug conjugate, exhibits the highest objective response rate in patients with HER2-overexpressing metastatic breast cancer, but clinical activity is also
Nature.com