Synaptotagmin
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Synaptotagmin - Wikipedia
WEBsynaptotagmins (SYTs) constitute a family of membrane -trafficking proteins that are characterized by an N-terminal transmembrane region (TMR), a variable linker, and two C-terminal C2 domains - C2A and C2B. There are 17 isoforms in the mammalian synaptotagmin family. [2] .
En.wikipedia.orgSynaptotagmin: A Ca 2+ sensor that triggers exocytosis? - Nature
WEBJul 1, 2002 · One of the proteins that has a crucial role in this secretion event is synaptotagmin I, an abundant constituent of synaptic vesicles that binds Ca2+ ions through two C2 domains.
Nature.comSynaptotagmin: Mechanisms of an electrostatic switch
WEBMar 23, 2020 · synaptotagmin is the Ca 2+ sensor that couples the Ca 2+ influx into nerve terminals following an action potential with this fast, synchronous vesicle fusion. Over two decades of synaptotagmin research has provided many clues as to how Ca 2+ binding by synaptotagmin may lead to vesicle fusion.
Pubmed.ncbi.nlm.nih.govSynaptotagmin-1: A Multi-Functional Protein that Mediates Vesicle
WEBThe vesicular protein synaptotagmin-1 (Syt-1) is the principal Ca 2+ sensor for fusion in several central nervous system neurons and neuroendocrine cells and part of the docking complex for secretory granules.
Pubmed.ncbi.nlm.nih.govThe calcium sensor synaptotagmin 7 is required for synaptic
WEBJan 6, 2016 · Here we show that synaptotagmin 7 (Syt7) is a calcium sensor that is required for facilitation at several central synapses. In Syt7-knockout mice, facilitation is eliminated even though the
Nature.comSynaptotagmin - an overview | ScienceDirect Topics
WEBsynaptotagmin is the Ca 2+ sensor that couples the Ca 2+ influx into nerve terminals following an action potential with this fast, synchronous vesicle fusion. Over two decades of synaptotagmin research has provided many clues as to how Ca 2+ binding by synaptotagmin may lead to vesicle fusion.
Sciencedirect.comSynaptotagmin-7 outperforms synaptotagmin-1 to promote the
WEBNov 27, 2023 · synaptotagmin-1 and synaptotagmin-7 are two prominent calcium sensors that regulate exocytosis in neuronal and neuroendocrine cells.
Nature.comSynaptotagmins: Beyond Presynaptic Neurotransmitter Release
WEBsynaptotagmins (Syts) are well-established primary Ca 2+ sensors to initiate presynaptic neurotransmitter release. They also play critical roles in the docking, priming, and fusion steps of exocytosis, as well as the tightly …
Pubmed.ncbi.nlm.nih.govThe Extended-Synaptotagmins - PMC - National Center for …
WEBThe synaptotagmins tether secretory vesicles, including synaptic vesicles, to the plasma membrane (PM) via their C2 domains and regulate their Ca 2+ triggered exocytosis.
Ncbi.nlm.nih.govMolecular basis for synaptotagmin-1-associated …
WEBJul 8, 2020 · At neuronal synapses, synaptotagmin-1 (syt1) acts as a Ca 2+ sensor that synchronizes neurotransmitter release with Ca 2+ influx during action potential firing. Heterozygous missense mutations in syt1 have recently been associated with a severe but heterogeneous developmental syndrome, termed syt1-associated neurodevelopmental …
Ncbi.nlm.nih.gov