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Subcutaneous Injection - an overview | ScienceDirect Topics
WEBsubcutaneous injection refers to injecting the drug in the fatty tissue layer of the subcutaneous tissue, which is present under the dermis and epidermis. Drug administration via this route can improve the bioavailability of drugs and prevent their absorption in the gastrointestinal tract. Hence, it is often used for the administration of drugs
Sciencedirect.comSubcutaneous Injection - an overview | ScienceDirect Topics
WEBsubcutaneous injection is a method of drug administration under the skin using a short needle pierce into the tissue layer between the skin and the muscle. To date, the subcutaneous injection method is highly recommended and very effective in administering drugs such as goserelin, insulin, morphine, and diacetylmorphine.
Sciencedirect.comTowards more tolerable subcutaneous administration: Review of
WEBJun 1, 2024 — Subcutaneous (SC) injection is a safe, effective, and increasingly accepted alternative route of administration for biotherapeutics. SC-administered biologics have seen steady growth in approvals by the US Food and Drug Administration (FDA) in recent years, with just over half of all approved injectables between 2017 and 2021 being SC products …
Sciencedirect.comOverview of authorized drug products for subcutaneous …
WEBJun 1, 2022 — subcutaneous injection volume of biopharmaceuticals-pushing the boundaries J. Pharm. Sci. , 105 ( 2016 ) , pp. 2255 - 2259 , 10.1016/j.xphs.2016.05.029 View PDF View article View in Scopus Google Scholar
Sciencedirect.comSubcutaneous Injection - an overview | ScienceDirect Topics
WEBIntravenous, intramuscular, and subcutaneous injections are commonly injection administration methods. Intravenous injection is a drug delivery method that involves directly injecting blood, drug liquid, and nutrient liquid into the vein, which is a frequent method of administration in in vivo experiments. subcutaneous injection is to inject
Sciencedirect.comSubcutaneous Antibiotic Therapy: The Why, How, Which Drugs …
WEBJan 1, 2021 — Concerning the type of antibiotic, infectious disease specialists and geriatricians reported previous use of the SC route for ceftriaxone (100%), ertapenem (33%), teicoplanin (39%), aminoglycosides (35%), and amoxicillin (15%). 6 However, routine SC administration of antibiotics worldwide is infrequent. 28,29.
Sciencedirect.comHydrogel-enabled, local administration and - ScienceDirect
WEBMay 1, 2023 — The hydrogel and payloads were administered via subcutaneous injection and resulted in DC expansion and activation and significantly slowed the tumor progression in both primary and secondary tumors. The combination of anti-CTLA-4 monoclonal antibody and GSNO demonstrated significant anti-tumor effects, while monotherapy with …
Sciencedirect.comInjectability as a function of viscosity and dosing materials for
WEBJan 10, 2019 — A novel needle for subcutaneous injection of interferon beta-1a: effect on pain in volunteers and satisfaction in patients with multiple sclerosis BMC Neurol. , 8 ( 38 ) ( 2008 ) 10.1186/1471-2377-8-38
Sciencedirect.comModeling drug transport and absorption in subcutaneous injection …
WEBAug 15, 2024 — Characterization of injection devices and pre-injection techniques. subcutaneous injection devices are essential for delivering medications beneath the skin’s surface. Two common types of these devices are prefilled syringes and auto-injectors (see Fig. 2). Prefilled syringes typically consist of a barrel that holds the medication, a plunger
Sciencedirect.comSubcutaneous injection of a bortezomib-loaded thermosensitive …
WEBJan 1, 2023 — Then, subcutaneous administration was approved in the US and EU in 2012, in addition to the intravenous injection route [11], [12]. Based on the results of the randomized phase trial, there was no significant difference in the overall and complete response (OR, CR) rates between the two administrations, and their elimination half …
Sciencedirect.com