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Sirtuin - Wikipedia
WEBsirtuins are a family of signaling proteins involved in metabolic regulation. [2] [3] They are ancient in animal evolution and appear to possess a highly conserved structure throughout all kingdoms of life. [2] Whereas bacteria and archaea encode either one or two sirtuins, eukaryotes encode several sirtuins in their genomes.
En.wikipedia.orgThe sirtuin family in health and disease | Signal Transduction and
WEBDec 29, 2022 · sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in numerous
Nature.comSirtuins as regulators of metabolism and healthspan - Nature
WEBMar 7, 2012 · sirtuins are crucial regulators of energy homeostasis, as they detect physiological changes in energy levels and modulate glucose and lipid metabolism accordingly.
Nature.comSirtuins, a promising target in slowing down the ageing process
WEBMar 3, 2017 · One of the most promising targets for anti-ageing approaches are proteins belonging to the sirtuin family. sirtuins were originally discovered as transcription repressors in yeast, however, nowadays they are known to occur in bacteria and eukaryotes (including mammals).
Ncbi.nlm.nih.govSirtuins and their Biological Relevance in Aging and Age-Related
WEBJul 23, 2020 · sirtuins, initially described as histone deacetylases and gene silencers in yeast, are now known to have many more functions and to be much more abundant in living organisms.
Ncbi.nlm.nih.govWhy Is Longevity Still a Scientific Mystery? Sirtuins—Past, …
WEBDec 31, 2022 · sirtuins are a group of proteins regulating many physiological functions and life processes. They have become an essential factor in research focused on aging processes as the deletion in the Sir-2 gene, which is responsible for the expression of sirtuins, results in a reduced lifespan of Saccharomyces cerevisiae [1].
Ncbi.nlm.nih.govSirtuins: the 'magnificent seven', function, metabolism and - PubMed
WEBWe review here the current knowledge regarding the role of sirtuins in metabolism, longevity, and discuss the possible therapeutic applications that could result from the understanding of their function in different organs and pathologies.
Pubmed.ncbi.nlm.nih.govRecent progress in the biology and physiology of sirtuins
WEBJul 30, 2009 · The sirtuins are a highly conserved family of NAD + -dependent enzymes that regulate lifespan in lower organisms. Recently, the mammalian sirtuins have been connected to an ever widening circle
Nature.comSirtuins, Aging, and Medicine | New England Journal of Medicine
WEBJun 9, 2011 · This review describes one such family of antiaging genes, the sirtuins, and details progress in understanding the biology that undergirds their promise as therapeutic targets.
Nejm.orgSirtuin - an overview | ScienceDirect Topics
WEBsirtuins are evolutionary conserved enzymes that function as NAD +-dependent deacetylases and ribosyltransferases [11]. Mammals have 7 sirtuins, which have a diverse distribution in the cell and regulate a variety of cellular functions including DNA repair, the cell cycle, and metabolism.
Sciencedirect.com