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Serine and one-carbon metabolism in cancer - Nature
WEBSep 16, 2016 — serine is a non-essential amino acid that can be taken up by the cell or synthesized de novo from glycolytic intermediates through the serine synthesis pathway (SSP). serine is used for many
Nature.comSerine Protease, Enzyme Catalysis | Learn Science at Scitable
WEBAug 24, 2010 — The first serine protease scientists explored in detail was chymotrypsin, a digestive enzyme synthesized in our pancreas, along with the related enzymes trypsin and elastase. It is transported to
Nature.comPHGDH: a novel therapeutic target in cancer - Nature
WEBJul 1, 2024 — serine is a key contributor to the generation of one-carbon units for DNA synthesis during cellular proliferation. In addition, it plays a crucial role in the production of antioxidants that
Nature.com303 See Other - Nature
WEB303 See Other. openresty
Nature.comInsulin-regulated serine and lipid metabolism drive peripheral
WEBJan 25, 2023 — serine and glycine restriction is widely used to modulate health outcomes in mice and is relatively well-tolerated for several months 16,19,20,21,22.To model the effect of systemic serine
Nature.comThe impact of physiological metabolite levels on serine uptake
WEBOct 26, 2021 — serine is a non-essential amino acid that is critical for tumour proliferation and depletion of circulating serine results in reduced tumour growth and increased survival in various cancer models.
Nature.comMycobacterium tuberculosis produces d-serine under hypoxia to …
WEBMay 28, 2024 — Hypoxia induces d-serine production by Mtb. To determine the metabolic responses of Mycobacteria to hypoxia, virulent Mtb H37Rv was cultured under hypoxic conditions using Wayne’s in vitro
Nature.comDesign strategy for serine hydroxymethyltransferase probes …
WEBFeb 20, 2019 — serine hydroxymethyltransferase (SHMT) is an enzyme that catalyzes the reaction that converts serine to glycine. It plays an important role in one-carbon metabolism. Recently, SHMT has been shown
Nature.comSerine hydroxymethyltransferase as a potential target of …
WEBJun 23, 2022 — serine hydroxymethyltransferase (SHMT) produces 5,10-methylenetetrahydrofolate (CH2-THF) from tetrahydrofolate with serine to glycine conversion. SHMT is a potential drug target in parasites
Nature.comSerine synthesis promotes bone degradation - Nature Metabolism
WEBJan 10, 2024 — serine synthesis may thereby have a dual role by (1) directing the expression of NFATc1 that is necessary to drive osteoclastogenesis and (2) ensuring the proper fuelling of differentiation. A
Nature.com