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辉瑞、莫德纳和强生计划推出 RSV 疫苗,年内或将向监管机构申 …
WEBNovavax rsv vaccine Pipeline NIAID: VRC-317 (DS-Cav1) 在进行基于 RSV F 蛋白融合前构象开发的疫苗产品前,不得不提到“DS-Cav1”,也就是 NIAID 团队开发的第一个融合前构象的 RSV F 蛋白疫苗设计,并在临床上进行了概念验证。具体设计就不多说了。
Zhihu.com全球首款呼吸道合胞病毒(RSV)疫苗获批上市,该疫苗功效如 …
WEBMay 4, 2023 · 所以开发rsv疫苗是一个很早就被提到议事日程上的事情,然而,从1957年发现rsv病毒,到现在,我们依然一款能用的rsv疫苗都没有。 这是为啥? 要说开发疫苗,最初RSV疫苗也没什么特别的,由辉瑞研发的福尔马林灭活疫苗,与当时上市的众多灭活疫苗类 …
Zhihu.com疫苗巨头打响专利战,GSK 起诉辉瑞 RSV 疫苗专利侵权,目前案 …
WEBAug 3, 2023 · 感兴趣的读者可以自行查阅。. 而GSK的RSV疫苗(Arexvy)实际上算是单价,从这个角度来说GSK直接告辉瑞侵权其实有点够呛。. 估计只能从氨基酸序列突变的角度来起诉辉瑞侵权。. 相关专利EP3275892B1其实早在2012年就申请了,确实要比辉瑞早。. 不过按照20年的保护期
Zhihu.com二手的科学家 的想法: 辉瑞RSV疫苗抗原设计 | 辉瑞RSV团队前几 …
WEBApr 19, 2023 · 辉瑞RSV疫苗抗原设计 | 辉瑞RSV团队前几日在STM杂志上在线发表了其RSV疫苗preF抗原设计和筛选细节,比此前公开的专利内容逻辑更清晰,也更加明确了其最终申报上市的preF抗原设计方案。
Zhihu.com关于呼吸道合胞病毒(RSV)的真实世界流行病学情况? - 知乎
WEB2.流行病学:. 呼吸道合胞病毒(RSV)每年可导致全球约340万例患者住院治疗,并导致至少6.6万人死亡; [1-2] 呼吸道合胞病毒(RSV)感染最常见于2岁以下婴幼儿,发病率约0.52% [1-2];. 新生儿期发病率约2.6%,0~6月龄患儿病情最为严重(年龄越小,越容易感染 …
Zhihu.com针对RSV疫苗的开发,为何国内还是落后这么多? - 知乎
WEB国内AdVaccine和Clover都临床自家RSV了,还有深信生物也开展了,石药也即将临床,达冕生物也临床了。. 石药号称2026就上市,这个姑且听听响就行。. 根据Clover自己公开的动物模型头对头结果,显示出GSK的单价有针对不涵盖另一型保护不够出色的缺陷。. AdVaccine采用
Zhihu.com辉瑞 RSV 疫苗上市申请获优先审评,这对老年人健康有哪些保 …
WEB二价RSV融合前F疫苗对老年人的有效性和安全性. Edward E Walsh. 呼吸道合胞病毒 (RSV)感染在老年人中引起相当多的疾病。. 在该人群中,一种研究用二价RSV融合前F蛋白疫苗 (RSVpreF)的有效性和安全性尚不清楚。. 在这项正在进行的3期试验中,我们以1:1的比 …
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WEBBMJ 杂志这两天发了一篇针对辉瑞可能即将上市针对孕妇群体免疫用于预防新生儿呼吸道合胞病毒 RSV 感染的疫苗的评论性文章。. 文章对 RSV 疫苗用于孕妇的安全性问题表达了一定程度的担忧。. 虽然 FDA 目前大多数票支持该疫苗的上市,但也有其中 4/14 人投票
Zhihu.com赛诺菲与阿斯利康旗下 Beyfortus,这对婴儿呼吸病治疗带来哪些 …
WEB结果证明,Beyfortus相较安慰剂可降低74.5%的RSV相关急性下呼吸道感染(如毛细支气管炎或肺炎)就诊率。. 作为为所有婴儿设计的 RSV 预防手段,Beyfortus 在多项临床试验中的不良反应发生率与生理盐水持平 [8]。. 去年底,上述研究被 Nature Medicine 列为“2022年将 …
Zhihu.com疫苗研发难吗? - 知乎
WEBrsv 疫苗占据整个传染病疫苗研发的 3%,主要得益于稳定构象的融合前 f 蛋白的突破性构建(2013 年科学十大进展之一)。 令人兴奋的是,两种 RSV 重组蛋白疫苗 PF-06928316 (辉瑞)和 GSK3844766A (葛兰素史克)在 III 期试验中产生了 >80% 的保护,并于 2023 年(分析截止日期后)获得 FDA 批准。
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