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Niraparib in Patients with Newly Diagnosed Advanced Ovarian …
WEBSep 28, 2019 · niraparib, an inhibitor of poly (adenosine diphosphate [ADP]–ribose) polymerase (PARP), has been associated with significantly increased progression-free survival among patients with recurrent
Nejm.orgniraparib | Cancer Care Ontario
WEBniraparib. Pronunciation: nye-RAP-a-rib. Other Name (s): Zejula. Appearance: tablet or capsule. Drug Formulary information is intended for use by healthcare professionals. It is not intended to be medical advice. Some of the information, including information about funding for cancer drugs, does not apply to all patients.
Cancercareontario.caNiraparib - Wikipedia
WEBniraparib, sold under the brand name Zejula, is an anti-cancer medication used for the treatment of epithelial ovarian, fallopian tube, or primary peritoneal cancer.
En.wikipedia.orgniraparib - Cancer Care Ontario
WEBniraparib is an inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP-1 and PARP-2, and acts to increase the formation of PARP-DNA complexes resulting in DNA damage, apoptosis and cell death. Increased cytotoxicity was observed in tumor cell lines with or without deficiencies in BRCA1/2.
Cancercareontario.caNiraparib Maintenance Therapy in Platinum-Sensitive, Recurrent …
WEBOct 8, 2016 · niraparib is an oral poly (adenosine diphosphate [ADP]–ribose) polymerase (PARP) 1/2 inhibitor that has shown clinical activity in patients with ovarian cancer. We sought to evaluate the efficacy
Nejm.orgNiraparib: A Review in First-Line Maintenance Therapy in …
WEBOct 11, 2021 · niraparib is a useful option for first-line maintenance therapy for advanced ovarian cancer in adults who responded to platinum-based chemotherapy, regardless of homologous-recombination deficiency status and is a promising option for HRp patients, for whom maintenance treatment options are limited.
Ncbi.nlm.nih.govAn In-Depth Review of Niraparib in Ovarian Cancer: Mechanism …
WEBAug 7, 2021 · niraparib is a potent and highly selective poly-ADP ribose polymerase (PARP) inhibitor. It is approved as a maintenance treatment for epithelial ovarian cancer which has demonstrated response to platinum chemotherapy.
Ncbi.nlm.nih.govNiraparib Uses, Side Effects & Warnings - Drugs.com
WEBAug 17, 2023 · niraparib is used as a "maintenance" treatment in adults to keep certain types of cancer from coming back. This includes cancers of the ovary, fallopian tube, or …
Drugs.comNiraparib (Zejula) | Cancer information | Cancer Research UK
WEBMar 31, 2023 · niraparib is a type of targeted cancer drug called a PARP inhibitor. It is also known as Zejula. It is a treatment for some types of ovarian, fallopian tube or primary peritoneal cancers. You pronounce niraparib as nir-rap-ar-ib. Find out about these different types of cancers.
Cancerresearchuk.orgThe efficacy and safety of niraparib for ovarian cancer: a single
WEBMay 17, 2021 · niraparib (Zejula®) is a highly selective inhibitor of PARP1/2 (nuclear proteins that detect DNA damage and promote its repair) [ 9 ]. In 2017, it was firstly approved for second-line maintenance treatment of ovarian cancer patients who were in complete or partial response to platinum-based chemotherapy by Food and Drug …
Ncbi.nlm.nih.gov