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mTOR - Wikipedia
WEBThe mammalian target of rapamycin (mtor), also referred to as the mechanistic target of rapamycin, and sometimes called FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the mtor gene.
En.wikipedia.orgmTOR Signaling in Growth, Metabolism, and Disease - PMC
WEBMar 3, 2017 · mtor is a serine/threonine protein kinase in the PI3K-related kinase (PIKK) family that forms the catalytic subunit of two distinct protein complexes, known as mtor Complex 1 (mtorC1) and 2 (mtorC2) (Fig. 1A). mtorC1 is defined by its three core components: mtor, Raptor (regulatory protein associated with mtor), and mLST8 …
Ncbi.nlm.nih.govmTOR-what does it do? - PubMed
WEBTOR Serine-Threonine Kinases. Target of rapamycin (TOR) is a highly conserved serine/threonine kinase that controls cell growth and metabolism in response to nutrients, growth factors, cellular energy, and stress.
Pubmed.ncbi.nlm.nih.govMultifaceted role of mTOR (mammalian target of rapamycin
WEBOct 2, 2023 · The mammalian target of rapamycin (mtor) is a protein kinase that controls cellular metabolism, catabolism, immune responses, autophagy, survival, proliferation, and migration, to maintain
Nature.commTOR pathway: A current, up-to-date mini-review (Review) - PMC
WEBOct 10, 2014 · Mammalian target of rapamycin (mtor) is a component of the phosphatidylinositol 3-kinase (PI3K) cell survival pathway that monitors the availability of nutrients, mitogenic signals and cellular energy and oxygen levels, and therefore is significant in the regulation of cell growth and proliferation .
Ncbi.nlm.nih.govmTOR as a central regulator of lifespan and aging - PMC
WEBJul 2, 2019 · mtor acts as a nutrient sensor coordinating cellular functions linked to proliferation, growth, and survival. mtor operates within two functionally and structurally distinct complexes: mtorC1 and mtorC2. The two mtor complexes share the components mLST8 and DEPTOR, while RAPTOR and PRAS40 are present exclusively …
Ncbi.nlm.nih.govmTOR signaling pathway and mTOR inhibitors in cancer: …
WEBMar 10, 2020 · Mammalian target of rapamycin (mtor) regulates cell proliferation, autophagy, and apoptosis by participating in multiple signaling pathways in the body. Studies have shown that the mtor signaling pathway is also associated with cancer, arthritis, insulin resistance, osteoporosis, and other diseases.
Cellandbioscience.biomedcentral.commTOR Signaling in Growth, Metabolism, and Disease: Cell
WEBThe mechanistic target of rapamycin (mtor) coordinates eukaryotic cell growth and metabolism with environmental inputs, including nutrients and growth factors.
Cell.commTOR kinase structure, mechanism and regulation | Nature
WEBMay 1, 2013 · The mammalian target of rapamycin (mtor), a phosphoinositide 3-kinase-related protein kinase, controls cell growth in response to nutrients and growth factors and is frequently deregulated in
Nature.commTOR inhibitors - Wikipedia
WEBmtor inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration.
En.wikipedia.org