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Cleavage and polyadenylation specificity factor - Wikipedia
WEBCleavage stimulation factor (CstF) has three subunits: CstF77 (CstF3), CstF50 (CstF1), and CstF64 (CstF2 and CstF2T). CstF recognizes the PAS that is 20 nucleotides downstream the signaling region of the cleavage site, which is a GU-rich sequence motif followed by U-rich sequences.
En.m.wikipedia.orgCleavage and Polyadenylation Specificity Factor - an overview
WEBAnother group of factors important for nuclear polyadenylation that may also function in the cytoplasm is cleavage and polyadenylation specificity factor (cpsf). cpsf, a complex of three proteins, is known for binding AAUAAA …
Sciencedirect.comStructural basis of AAUAAA polyadenylation signal recognition - Nature
WEBJan 22, 2018 · The PAS hexamer motif is specifically recognized by the cpsf, a multisubunit complex responsible for polyadenylation-site definition, pre-mRNA cleavage and poly (A)-polymerase recruitment
Nature.comRole of cleavage and polyadenylation specificity factor 100: anchoring
WEBJun 16, 2017 · Cleavage and polyadenylation specificity factor (cpsf) is a key protein complex for polyadenylation. It contains six subunits, including cpsf30, Wdr33 (plant homologue FY), Fip1, cpsf73, cpsf100 and cpsf160 (Shi et al., 2009; Schönemann et al., 2014; Michalski and Steiniger, 2015).
Onlinelibrary.wiley.comPolyadenylation factor CPSF-73 is the pre-mRNA 3'-end - Nature
WEBNov 26, 2006 · Purified recombinant cpsf-73 possesses RNA endonuclease activity, and mutations that disrupt zinc binding in the active site abolish this activity.
Nature.comCleavage and Polyadenylation Specificity Factor - an overview
WEBCleavage and Polyadenylation Specificity Factor. The Cleavage and Polyadenylation Specificity Factor 6 (cpsf6), also known as CFIm68, is a 68-kDa subunit of the Cleavage Factor I mammalian (CFIm) complex.
Sciencedirect.comAlternative Polyadenylation: a new frontier in post transcriptional
WEBNov 25, 2020 · Working as a complex, cpsf recognizes the polyadenylation signal sequence AAUAAA and cleaves the pre-mRNA. This provides sequence specificity that may play an important role in regulating pA site selection, gene expression, cancer cell migration, metastasis, and eventually disease outcome [ 32 ].
Biomarkerres.biomedcentral.comCPSF3-dependent pre-mRNA processing as a druggable node in AML - Nature
WEBDec 9, 2019 · The cpsf complex is composed of at least five proteins (cpsf1, cpsf2, cpsf3, cpsf4 and FIP1L1) that recognizes the canonical nucleotide sequence AAUAAA in a newly synthesized pre-messenger RNA
Nature.comCPSF1 cleavage and polyadenylation specific factor 1 [ (human)]
WEBAug 27, 2024 · Cleavage and polyadenylation specificity factor (cpsf) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. cpsf recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly (A) synthesis.
Ncbi.nlm.nih.govCPSF6 regulates alternative polyadenylation and - Cell Press
WEBOct 31, 2023 · Here, we find that cpsf6 can undergo liquid-liquid phase separation (LLPS), and elevated LLPS is associated with the preferential usage of the distal poly (A) sites. CLK2, a kinase upregulated in cancer cells, destructs cpsf6 LLPS by phosphorylating its arginine/serine-like domain.
Cell.com