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Related websites
What Is the COMT Gene? And How Does It Affect …
WEBNov 30, 2023 · What is it? The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. An estimated 20-30% of Caucasians of European ancestry have a COMT gene variation which
Psychologytoday.comDopamine-Dependent Cognitive Processes after Menopause: The
WEBThe decreased frontal activation as dopamine increased was interpreted as more cognitively “efficient”. The current study was the first to examine how COMT genotype …
Ncbi.nlm.nih.govComplex estrogenic regulation of catechol-O-methyltransferase …
WEBCatechol-O-methyltransferase (COMT) activity depends on gender, age and physiological status suggesting that estrogen may regulate COMT activity. In fact, estrogens down …
Pubmed.ncbi.nlm.nih.govCatechol-O-methyltransferase: characteristics, polymorphisms …
WEBO -Methylation by catechol- O -methyltransferase (COMT) blocks their estrogenicity and prevents their oxidation to quinones. A single gene encodes both membrane bound …
Ncbi.nlm.nih.govCatechol-O-methyl transferase suppresses cell invasion and …
WEBO -Methylation by catechol- O -methyltransferase (COMT) blocks their estrogenicity and prevents their oxidation to quinones. A single gene encodes both membrane bound …
Nature.comEstradiol and the Catechol-o-methyltransferase Gene Interact to …
WEBJul 1, 2023 · Genetic and hormonal factors can shape individual differences in prefrontal DA tone. The catechol-o-methyltransferase (COMT) gene regulates basal prefrontal DA, and …
Ncbi.nlm.nih.govCatechol‐O‐Methyltransferase and Cardiovascular …
WEBDec 16, 2019 · Genetic variation in catechol‐O‐methyltransferase (COMT), a key enzyme in estrogen and catecholamine metabolism, has plausible physiological links to cardiovascular disease (CVD) and its risk factors.
Ahajournals.orgEstrogen down regulates COMT transcription via promoter DNA …
WEBMar 15, 2019 · Catechol-O-methyltransferase (COMT) acts as a 'gate-keeper' to prevent DNA damage during estrogen metabolism. Both experimental and epidemiological …
Pubmed.ncbi.nlm.nih.govThe Effects of Catechol-O-Methyltransferase Inhibition on …
WEBOct 1, 2001 · O-Methylation catalyzed by catechol-O-methyltransferase (COMT) is a Phase II metabolic inactivation pathway for catechol estrogens.
Aacrjournals.orgEstrogen down regulates COMT transcription via promoter DNA …
WEBMar 15, 2019 · Catechol- O -methyltransferase (COMT) acts as a ‘gate-keeper’ to prevent DNA damage during estrogen metabolism. Both experimental and epidemiological …
Sciencedirect.comDeficiency in catechol-o-methyltransferase is linked to a - Nature
WEBAug 11, 2017 · 2-methoxyestradiol (2-ME), an estrogen metabolite generated via catechol-o-methyltransferase (COMT), is multifunctional methoxy-catechol. Here, we …
Nature.comCharacterization and Implications of Estrogenic Down-Regulation …
WEBJul 1, 1999 · Our findings provide the first evidence and molecular mechanism for estrogen to inhibit COMT gene transcription, which may shed new insight into the role of estrogen …
Molpharm.aspetjournals.orgEstradiol and the Catechol-o-methyltransferase Gene Interact
WEBJul 1, 2023 · The catechol-o-methyltransferase (COMT) gene regulates basal prefrontal DA, and the sex hormone 17β-estradiol potentiates DA release. E. Jacobs and M. D'Esposito …
Pubmed.ncbi.nlm.nih.govCatechol-O-Methyltransferase (COMT): An Update on Its Role in …
WEBApr 30, 2017 · Catechol- O -methyltransferase (COMT) is an enzyme that catalyses the methylation of catechol substrates, classically in catecholamine metabolism, but also …
Link.springer.comCatechol-O-Methyltransferase (COMT): A Gene Contributing to …
WEBSep 5, 2007 · Sex-specific effects of COMT are usually attributed to transcriptional regulation by estrogens; however, additional mechanisms are likely to be at least as …
Nature.comThe Complete Guide to the COMT Mutation and Adrenal Fatigue
WEBCOMT is essential for ridding your body of harmful estrogen metabolites. So, if you have excess estrogen in your body, then it will slow COMT activity, which will lead to a build …
Drlamcoaching.comEstrogen Metabolism and Breast Cancer - PMC - National Center …
WEBJan 1, 2015 · COMT is a phase II enzyme that inactivates catechol estrogens by conjugating them into nongenotoxic methoxyestrogens . COMT also prevents biotransformation of …
Ncbi.nlm.nih.govCatechol-O-Methyltransferase (COMT)-mediated Metabolism of …
WEBSep 1, 2001 · Catechol- O -methyltransferase (COMT) catalyzes the methylation of catechol estrogens to methoxy estrogens, which simultaneously lowers the potential for DNA …
Aacrjournals.orgCharacterization and implications of estrogenic down-regulation of
WEBOur findings provide the first evidence and molecular mechanism for estrogen to inhibit COMT gene transcription, which may shed new insight into the role of estrogen in the …
Pubmed.ncbi.nlm.nih.govWhat Is COMT? DNA-Based Nutrition | Nutrition Genome
WEBFeb 7, 2016 · What is COMT? COMT (Catechol-O-Methyltransferase) breaks down estrogen, catecholamines and neurotransmitters including dopamine, epinephrine and …
Nutritiongenome.comA genetic variant in the catechol-O-methyl transferase (COMT) …
WEBJul 28, 2017 · The estrogen-dependent regulation of COMT expression induces a sexually dimorphic effect of rs4680 on COMT activity, leading to the observation that specifically …
Ncbi.nlm.nih.govCatechol-O-Methyltransferase and Cardiovascular Disease: MESA
WEBDec 17, 2019 · Background Genetic variation in catechol-O-methyltransferase (COMT), a key enzyme in estrogen and catecholamine metabolism, has plausible physiological …
Pubmed.ncbi.nlm.nih.govCatechol-O-methyltransferase (COMT)-mediated metabolism of …
WEBSep 15, 2001 · Catechol-O-methyltransferase (COMT) catalyzes the methylation of catechol estrogens to methoxy estrogens, which simultaneously lowers the potential for DNA …
Pubmed.ncbi.nlm.nih.gov