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    Related websites

    Familial breast and ovarian cancer - RACGP

    WEBSep 6, 2022 · The lifetime risk of breast cancer in Australian women is approximately one in eight. Pathogenic variants of the BRCA1 and brca2 genes increase the chance of developing breast cancer to about 70% (cumulative risk to 80 years of age). Despite this, BRCA1 and brca2 variants account for only about 5% of all breast cancer cases, …

    Racgp.org.au


    Wake of Angelina – managing a family history of breast cancer

    WEBAt present, even in families with a strong family history of breast cancer, the mutation detection rate for BRCA1 and brca2 in the absence of ovarian cancer is 10–15%, 5 and if ovarian cancer is present it is about 50–55%. 6 Such testing is often uninformative in that it has not detected a genetic cause for the family, and yet there is

    Racgp.org.au


    CLINICAL PRACTICE with a family history of - RACGP - The …

    WEBbrca2.5 The initial step in genetic testing is usually to take blood from one of the family members affected by breast or ovarian cancer (although sometimes an unaffected obligate carrier may be tested instead). The decision concerning which genes to test is based on the family history. This first phase, the ‘mutation search’,

    Racgp.org.au


    RACGP - Breast cancer

    WEBMember of a family in which the presence of a high-risk breast cancer gene mutation (eg BRCA1, brca2) has been established There are multiple risk factors for breast cancer (genetic, hormonal, lifestyle and environmental). 3 However, BreastScreen, Australia’s national breast cancer screening program, focuses on age, inviting all Australian women …

    Racgp.org.au


    RACGP - Prevention and early detection of breast cancer

    WEBConsider annual mammography starting at age 40 years if relative with breast cancer aged <50 years. Consider referral to family cancer clinic or specialist cancer clinic, where available, for further assessment of risk of developing cancer and advice about genetic testing, screening and prevention. Every 1–2 years. GPP.

    Racgp.org.au


    Familial prostate cancer - RACGP

    WEBSep 6, 2022 · of the BRCA1 or brca2 genes (high risk). These individuals should be referred to a family cancer clinic. These individuals should be referred to a family cancer clinic. Men with family history of prostate cancer who decide to be tested should be offered prostate-specific antigen (PSA) testing every two years from 40 or 45 years of age, with …

    Racgp.org.au


    Gynaecological malignancies Ovarian cancer screening - RACGP

    WEBBRCA1, brca2 and hereditary nonpolyposis colorectal cancer (HNPCC). Only 0.2% of the population carry a germline mutation in BRCA1 or brca2, unless they are of Ashkenazi Jewish descent when the incidence is 2%. If a Jewish woman is diagnosed with ovarian cancer there is a 30–60% risk of a germline mutation.5 If a woman has

    Racgp.org.au


    RACGP - Investigation and management of an ovarian mass

    WEBDiscussion. Investigation for an ovarian mass includes both transvaginal and transabdominal ultrasound. Simple, anechoic cysts <5 cm in premenopausal women are likely to be benign and do not require further follow-up. The use of the cancer antigen 125 (Ca125) tumour marker can be unreliable in premenopausal women given the low …

    Racgp.org.au


    RACGP - Genetics in general practice

    WEBMen with a first-degree relative with familial breast cancer (BRCA1 or brca2) Respond to requests for screening by informing patients of risks and benefits of screening; Note that routine screening of the general population for prostate cancer is not recommended 28 unless: the man specifically asks for it; and; he is fully counselled on the

    Racgp.org.au


    RACGP - Investigation of a new breast symptom: a guide for …

    WEBOverview. This guide has been approved as an Accepted Clinical Resource. The Guide advises steps to take in investigating symptoms that could be breast cancer, and provides information about the triple test approach to diagnosis. Investigation of a new breast symptom: a guide for General Practitioners.

    Racgp.org.au


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